Hypoxic cells can acquire a mutator phenotype that consists of decreased DNA repair, an increased mutation rate and increased chromosomal instability. Defects in homologous recombination and ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

The breakdown in this ongoing dance of DNA damage and repair is one of the root causes ... have few effective treatment options outside of surgery, and it's not uncommon for these tumors to ...

"The surprising result of our research is that DNA repair, which normally protects healthy cells, determines how cancer cells die following radiotherapy," said Prof Cesare. "The DNA inside our ...

For this reason, they are at greater risk of accumulating damage and must develop alternative repair pathways to avoid dysfunction. Scientists do not understand how neuronal DNA damage is ...