Understanding how the dystrophin and utrophin protein networks interact with other cellular components may reveal novel characteristics of cytoskeletal function and adaptability. We hypothesized ...

DMD is an X-linked disorder characterized by progressive muscle weakness and wasting due to the absence of a protein called dystrophin, which in turn causes degeneration of skeletal and cardiac muscle ...

Dystrophin is part of a protein complex linking the cytoskeleton of muscle fibers to the surrounding connective tissue (basal lamina). It’s a long protein with numerous redundant coils (purple balls), ...

The study could provide the basis for new therapeutic approaches. Increase in the production of utrophin Besides dystrophin, the study focuses on a second protein called utrophin, which is related to ...

These findings were validated in mdx mice, a well-established animal model of DMD ... that aim to replace or repair the missing dystrophin protein, K884 focuses on bolstering the natural repair ...