FIVE schemes for biosynthesis of the lysergic acid moiety of the ergot alkaloids have been proposed recently. All of them involve tryptophan or 5-hydroxytryptophan as precursors 1,2.

Ergot alkaloids are a diverse group of natural compounds produced by certain fungi, particularly those in the genus Claviceps. These compounds have significant pharmacological properties and are ...

While the mechanism involved is not fully understood, research has shown that ergot alkaloids can be found in grain previously considered unaffected or healthy, both above and below the infection ...

Ergot alkaloids (ergotamine, dihydroergotamine) are used in patients with frequent, moderate migraine, but are less effective than triptans. There are several agents for prevention of migraine ...

Ergot alkaloids were the first antimigraine drugs available. Dihydroergotamine (DHE) is an ergotamine analog (Figure 3). DHE is administered as a nasal spray form (Migranal®, Valeant ...

Ergolines-structurally related to alkaloids naturally found in ergot fungi-hold broad potential in areas ranging from neurological research and psychiatric applications to treatments for migraines ...