Recent research has shed light on the complex regulation of erythroid cells, revealing their multifaceted roles not only in oxygen transport but also in immune responses and disease contexts.

Castruccio Castracani and his team developed a lentiviral vector that activated the human ALAS2 gene in erythroid cells, or cells that serve as precursors to normal red blood cells. They found ...

Dosing with the BEAM-103 mAb led to rapid and near complete replacement of wild-type erythroid cells by edited cells, leading to early induction of therapeutically relevant levels of HbF.