Estrogen helps protect against cardiovascular (heart-related) disease and supports bone health. Drops in estrogen can make you more vulnerable to cardiovascular conditions, such as elevated ...

Total serum cortisol and CBG levels were higher in subjects taking oral estrogens than in controls (P <0.001); however, levels in subjects taking transdermal estrogen were similar to controls.

Estrogen production declines slowly during perimenopause, which typically starts in the mid- to late 40s, then drops precipitously as menopause begins. What exactly does estrogen loss do to your face?