Here we show a unique and previously unrecognized mechanism of drug action in which Et743 subverts normal nucleotide excision repair (NER ... Total cellular RNA was used to synthesize cDNA ...

Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya; the intron is usually located in the anticodon loop of the pre-tRNA and must be removed precisely ...

Repair reactions involve the excision of chemically altered or mispaired bases from the DNA duplex. Resulting gaps are filled in by DNA polymerases; this reaction leaves a nick at or flanking the site ...

But Storici's team found that RNA can also help cells repair a severe form of DNA damage called a double-strand break, or DSB. A DSB means both strands of the DNA helix have been severed.