Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

which leads to degradation of the extracellular matrix by matrix metalloproteinases (MMPs; Figure 4). Following activation of MMPs, angiogenesis is initiated by vascular endothelial growth factor ...

A 3D model accurately mimicking the blood-brain barrier (BBB) in a laboratory environment has been successfully developed by ...

More information: Maria Faleeva et al, Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness, Circulation Research (2024). DOI: 10.1161/CIRCRESAHA.

The Mechanobiology Lab explores how adherent cells can sense and respond to the mechanical stiffness of the extracellular matrix. The goal of the Vascular Engineering Lab is to develop novel ...

To this end, human vascular smooth muscle cells ... expressed genes were associated with extracellular processes and extracellular matrix interaction terms. Extracellular region and space were ...

Discover how a revolutionary 3D Blood-Brain Barrier model advances the understanding of neurodegenerative diseases and drug ...

Atherosclerosis involves multiple processes including endothelial dysfunction, inflammation, vascular proliferation and matrix alteration. Vascular proliferation contributes to the pathobiology of ...

Researchers develop 3D blood-brain barrier model to study Alzheimers and neuroinflammation New platform created to improve understanding of neurodegenerative diseases through innovative testing ...