Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Physiological extracellular matrix (ECM) calcification or mineralization is restricted to bones, teeth and the hypertrophic zone of growth plate cartilage. In contrast, pathological ECM ...

A 3D model accurately mimicking the blood-brain barrier (BBB) in a laboratory environment has been successfully developed by ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or ... deposition of scar molecules, vascular and organ contraction, and ...

The Mechanobiology Lab explores how adherent cells can sense and respond to the mechanical stiffness of the extracellular matrix. The goal of the Vascular Engineering Lab is to develop novel ...

To this end, human vascular smooth muscle cells ... expressed genes were associated with extracellular processes and extracellular matrix interaction terms. Extracellular region and space were ...

Atherosclerosis involves multiple processes including endothelial dysfunction, inflammation, vascular proliferation and matrix alteration. Vascular proliferation contributes to the pathobiology of ...

Discover how a revolutionary 3D Blood-Brain Barrier model advances the understanding of neurodegenerative diseases and drug development.