Inhibiting GLS1 reduced high blood pressure in the right side of the heart of PAH rats and improved various measures of heart ...

Previous reports have found unbalanced glutamate-glutamine cycle in the medial prefrontal cortex of mice with depression, which led to the interest in glutamine synthetase as a potential therapeutic ...

HD is caused by an expanded glutamine repeat in the N-terminal region of the huntingtin (HTT ... A few antipsychotic drugs and other medications have shown efficacy in treating the symptoms of the ...

which involves alteration of glutamine metabolism, resulting from increased expression of Glul, a gene encoding an enzyme that converts glutamate to glutamine. Importantly, they found that this ...