近年来，国内外大量研究均已表明，HBV在肝内形成的共价闭合环状DNA（HBV cccDNA）库的持续存在与HBV慢性持续性感染以及慢性乙型肝炎（CHB）难以治愈密切相关。HBV cccDNA的彻底清除不仅是判定HBV感染彻底治愈的重要指标，也是终止CHB进展为肝硬化、肝细胞癌（HCC ...

HBV在肝内形成的共价闭合环状DNA（HBV cccDNA）库的持续存在与HBV慢性持续性感染以及慢性乙型肝炎（CHB）难以治愈密切相关。HBV cccDNA的彻底清除不仅 ...

导语慢性乙型肝炎（chronichepatitisB，CHB）是由乙型肝炎病毒（hepatitisBvirus，HBV）感染引起的全球重大公共卫生问题，据世卫组织报道，2019年全球约有2.96亿慢性HBV感染者，82万人死于慢性HBV感染导致的肝硬 ...

The definition and clinical use of common HBV serological markers are shown in Table 2. HBsAg is the hallmark of HBV infection and is the first serological marker to appear in acute hepatitis B.

This nuclease targets a conserved sequence within the HBV genome, focusing on the elimination of cccDNA and the inactivation of integrated HBV genomes. The ARCUS platform, based on a naturally ...

即 pgRNA 载量下降最高达到原来的约 1/32），间接体现了对 HBV cccDNA 的潜在有效抑制和耗竭作用，有望解决慢性乙肝 LLV 患者未被满足的临床需求 ...

the design of PBGENE-HBV to directly eliminate cccDNA and inactivate integrated HBV DNA with high specificity, potentially leading to functional cures; the suitability of ARCUS nucleases for gene ...