近年来，国内外大量研究均已表明，HBV在肝内形成的共价闭合环状DNA（HBV cccDNA）库的持续存在与HBV慢性持续性感染以及慢性乙型肝炎（CHB）难以治愈密切相关。HBV cccDNA的彻底清除不仅是判定HBV感染彻底治愈的重要指标，也是终止CHB进展为肝硬化、肝细胞癌（HCC ...

HBV复制率高，每天约产生1万亿个完整的病毒颗粒，以及只含HBsAg的亚病毒颗粒，后者不能复制，也不能感染，但其含量较完整的HBV高1 000～100 ...

HBV在肝内形成的共价闭合环状DNA（HBV cccDNA）库的持续存在与HBV慢性持续性感染以及慢性乙型肝炎（CHB）难以治愈密切相关。HBV cccDNA的彻底清除不仅 ...

目前，先降低病毒负荷、再免疫调节治愈的路径已经达成共识。由此可见，我们依然需要新的更强的DAA药物。在慢性乙肝治疗的新药开发上，我国政府部门的态度则更加务实。如中国国家药监局药品审评中心（CDE）最近批准了已知HBVDNA复制作用更加明显的NA类新药 ...

即 pgRNA 载量下降最高达到原来的约 1/32），间接体现了对 HBV cccDNA 的潜在有效抑制和耗竭作用，有望解决慢性乙肝 LLV 患者未被满足的临床需求 ...

Despite numerous treatment advances, chronic hepatitis B virus (HBV) infection remains a largely incurable disease impacting more than 290 million people worldwide. All patients with chronic HBV ...

The definition and clinical use of common HBV serological markers are shown in Table 2. HBsAg is the hallmark of HBV infection and is the first serological marker to appear in acute hepatitis B.

Dagger; Approximately five copies = 1 IU. ALT: Alanine aminotransferase; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus. IgM anti-HBc Presence with high index value during acute HBV ...

This nuclease targets a conserved sequence within the HBV genome, focusing on the elimination of cccDNA and the inactivation of integrated HBV genomes. The ARCUS platform, based on a naturally ...

ImmuneMed is developing both its phase 2-ready antiviral drug candidate hzVSF to treat viral diseases including chronic hepatitis B virus (HBV) infection and a line of rapid diagnostic kits to ...