尽管 HER2 - low 和 HER2 - ultralow 乳腺癌的治疗前景逐渐明朗，但目前仍存在诸多问题。一方面，中国患者中 HER2 - low 和 HER2 - ultralow 表达的高质量数据匮乏，现有数据多基于历史结果，且主要针对 HER2 阳性人群。另一方面，IHC 和 ISH 检测中，不同观察者之间的评分差异较大，尤其是在 0 - 1 + 评分区间，这给 HER2 - low ...

All positive (IHC 3+) and doubtful (IHC 2+) cases were screened by fl uorescence in situ hybridization (FISH). Patients with HER2 gene amplification, normal left ventricular ejection fraction ...

随着抗HER2抗体偶联药物(ADC)的临床应用，HER2低表达乳腺癌的预后价值引发争议。韩国多中心团队通过倾向评分匹配分析1627例I-III期患者数据，发现HER2-low与HER2-zero组在总生存(OS)、无复发生存(RFS)等指标上无显著差异，但在淋巴结转移亚组中HER2-low患者RFS更优。

For example, people with breast cancer have more copies of a gene called HER2. More HER2 genes in a FISH test mean more HER2 receptors in breast cells with which they can bind. These receptors can ...

Future Oncol. 2015;11(7):1023-1026. Tumor-negative breast cancers misclassified as HER2 negative by IHC (0 or 1+) could therefore be reclassified by FISH, with a remarkable impact on medical ...

Fatty fish, egg yolks, mushrooms exposed to ultraviolet ... as they likely will not provide the nourishment your body needs while living with HER2-negative breast cancer. If you are experiencing ...