Hemoglobin has played a central role in the understanding of many biochemical and biophysical principles, as Eaton and colleagues point out on page 351 of this issue of Nature Structural Biology.

IN 1955 Rucknagel et al. 1 described a new abnormal hemoglobin in a Negro family in North Carolina. This hemoglobin, designated "I", migrated more rapidly than normal hemoglobin on filter-paper ...

CHOIR = Correction of Hemoglobin and Outcomes in Renal Insufficiency; MI = myocardial infarction; CHF = congestive heart failure; K-M = Kaplan-Meier; CI = confidence interval Ajay K. Singh ...