They exert their effect by binding to antithrombin, which inhibits both activated factor X and thrombin via a specific ... unfractionated heparin (UFH) and low molecular weight heparin (LMWH ...

In summary, despite the safety profile and long history of heparin use, there are drawbacks that mandate that we continue to look for alternatives for our patients. Direct inhibition of thrombin ...

Melagatran effectively inhibits both free and clot-bound thrombin—a potential pharmacodynamic advantage over heparin products. Melagatran has a half-life of 2.4–4.6 hours, necessitating twice ...

Heparin, commonly used in this field ... to link the two molecules that bind to thrombin. Two strands of PNA can come together via relatively weak bonds that are easy to break.

In March 2008, the European Commission granted marketing authorization for dabigatran etexilate (Pradaxa; Boehringer Ingelheim), a direct thrombin ... molecular-weight heparin, warfarin or ...

Low molecular weight heparin (LMWH) is an anticoagulant injected subcutaneously or intravenously and acts via activation of antithrombin III which in turn inactivates thrombin and factor Xa to ...