Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system.

Epigenetic modifications such as DNA methylation and histone acetylation contribute to ... It has been shown that DNA methylation and histone deacetylation at the FLI1gene contribute to the ...

Mechanisms that have been characterized in SSc include DNA methylation and histone acetylation and deacetylation. Both DNA methyltransferase inhibitors and HDAC inhibitors have been successfully ...

Subsequent studies revealed that not only histones but also numerous non-histone proteins are ... "This forms an acetylation and deacetylation cycle of Bub1 in the cell cycle," Dr.