Targeted de novo methylation during development involves SET domain-containing proteins that are capable of specifically methylating histones as well as recruiting DNA methyltransferases.

DNA methylation is one of several epigenetic ... DNA also form complexes with the proteins involved in deacetylation of histones. Therefore, when DNA is methylated, nearby histones are ...

However, the study shows that LSD1 not only affects gene expression in the way previously assumed by altering histones ... for other proteins that control DNA methylation. The researchers were ...

In an experiment using the drug RG108, which blocks DNA methyltransferases, scientists observed a significant deterioration in the level of potentiation of synaptic responses, which confirms the ...

in the DNA sequence. Methylation can lead to gene silencing by preventing transcription factors from binding to the promoter region of a gene. Histones are proteins that package and order DNA into ...

In some patients receiving long-term therapy, mutations in target molecules or aberrant DNA methylation can cause chromatin structure reaggregation, leading to clinical relapse. News organizations ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

The mechanism of a peculiar type of heterochromatin, used by embryonic stem cells to silence 'parasitic' DNA-elements within the context of their highly dynamic pluripotent chromatin. Disclaimer ...