Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...
Molecular chaperones like HSP90 can promote folding of damaged ... of ribosomal S6 kinase and decreased sensitivity to the mTOR inhibitor rapamycin 1. Thus, Hsf1 increases the activity of the ...
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