A new review was published in Oncotarget, Volume 16, on February 12, 2025, titled “SETDB1 amplification in osteosarcomas: ...

"We've known for years that osteosarcoma cells have some of the most complex genomes seen in human cancers, but we couldn't explain the mechanisms behind this," said Isidro Cortes-Ciriano ...

virus in siRNA-treated osteosarcoma cells and identified 312 human genes that regulated susceptibility or resistance to influenza PR8 virus infection. Notably, they demonstrated that interferon ...

New research using data from the 100,000 Genomes Project has identified a genetic change that drives osteosarcoma, an ...

"We've known for years that osteosarcoma cells have some of the most complex genomes seen in human cancers, but we couldn't explain the mechanisms behind this," said Isidro Cortes-Ciriano ...

Isidro Cortes-Ciriano, Group Leader at EMBL-EBI and co-senior author of the study, said: "We've known for years that osteosarcoma cells have some of the most complex genomes seen in human cancers ...

Bone cancer is characterized by uncontrolled growth of cells of the bone. Primary bone cancer (that arises directly in the bone), is relatively rare. Different types of bone tissue give rise to ...

Our team has demonstrated the presence of SETDB1 abnormalities, particularly its amplification, through WES analysis of osteosarcoma human samples ...

Importantly, this success was achieved without harming healthy human bone cells. Osteosarcoma is one of the most common ...

In the Ebola experiments, Lacy-Hulbert, Bruchez, and their colleagues had been using a genetic screen called transposon-mediated gene activation to search for natural antiviral mechanisms within ...

These are symptoms that about 1,000 people in the United States begin to feel each year shortly before being diagnosed with osteosarcoma ... This variation allows cells in different parts of ...