Nature3 年
Gene transcription factor inhibitors: a novel class of therapeutics modulating gene expression
Selectively controlling gene expression by directly targeting specific gene transcription factors (GTFs ... company to build a pipeline of novel GTF inhibitors, establishing Cellestia as a ...
CU Boulder News & Events4 年
Transcription Factors and PIC function
Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...
Nature1 年
Do Transcription Factors Actually Bind DNA? DNA Footprinting and Gel Shift Assays
However, in the presence of the transcription factor Sp1, a range of band sizes ... an agent that chelates metal ions, inhibits zinc binding. Thus, notice that in the lane with EDTA, the binding ...
BioWorld4 天
New inhibitor of the noncanonical NF-κB pathway specifically binding to RelB shows ...
The transcription factor nuclear factor-κB (NF-κB) family has a central regulatory role in the expression of many genes related to immune responses, inflammation, cell survival and cancer. Previous ...
Researchers identify Lhx2 as key gene in hepatic stellate cells regulating liver ...
A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...