Selectively controlling gene expression by directly targeting specific gene transcription factors (GTFs ... company to build a pipeline of novel GTF inhibitors, establishing Cellestia as a ...
However, in the presence of the transcription factor Sp1, a range of band sizes ... an agent that chelates metal ions, inhibits zinc binding. Thus, notice that in the lane with EDTA, the binding ...
The ∆40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation. PLoS Biol 2021, 19: e3001364. Schier, A; Taatjes, DJ ...
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Transcription factor found to play pivotal role in development of right-sided colon cancersThe transcription factor CDX2—which plays an important ... "Colon cancers are very notorious in that they develop resistance to these inhibitors," he says. "There's a lot of interest in trying ...
New inhibitor of the noncanonical NF-κB pathway specifically binding to RelB shows antitumor effect
The transcription factor nuclear factor-κB (NF-κB) family has a central regulatory role in the expression of many genes related to immune responses, inflammation, cell survival and cancer. Previous ...
A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...
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