Several lines of evidence link metabolic dysregulation to late-life neurodegenerative diseases. The altered glucose ...

Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

Blocking adrenomedullin’s effects restores insulin function and improves glucose control in a mouse model, suggesting a potential new target for treating obesity-related metabolic disease.

"Insulin binding to InsRα derepresses the tyrosine kinase activity of the β-subunit (InsRβ). This initiates a whole metabolic pathway with different steps that eventually allow glucose ...

A study in Nutrients finds regular mango intake boosts insulin sensitivity and fights inflammation in overweight or obese ...

Insulin is a vital hormone that controls numerous processes in the body—from blood glucose (blood sugar ... such as in the so-called mTOR signaling pathway—a key regulator of cell division ...