Insulin-like growth factor (IGF) 1 is a member of a family that is involved ... IGF1, IGF2 and insulin act primarily through tyrosine-kinase-linked receptors—the IGF1 receptor (IGF1R) and ...

CHO cells stably expressing IGF-1R or insulin receptor (IR) were 'serum-starved' for 2 h, incubated with JB3 for 20 min at 37 °C, then incubated with 100 nM IGF-1 (for CHO.IGF-1R cells ...

Heterocyclic insulin-like growth factor 1 receptor (IGF-1R; CD221) inhibitors potentially useful for the treatment of thyroid-associated ophthalmopathy (Graves’ ophthalmopathy) have been disclosed in ...

Secondary lymphedema occurs when, after surgery or radiotherapy, the lymphatic system cannot drain interstitial fluid effectively, leading to inflammation and fluid accumulation in the limbs. Previous ...

The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

A research team revealed that insulin-like growth factor-binding protein 6 (IGFBP6) serves as a potential therapeutic target for suppressing endothelial inflammation and atherosclerosis.

Alumis and Acelyrin have announced a definitive merger agreement, which will result in an all-stock transaction, creating a ...

Salk Institute researchers have identified a key protein that may help users of GLP-1 drugs such as Ozempic and Wegovy maintain muscle mass while losing weight.

we found that ADM2 facilitates the expression of insulin-like growth factor 2 (IGF-II), which then triggers the activation of the AKT-GSK3β-mTOR signaling pathway via the IGF-II receptor (IGF-IIR ...

In a phase IIb/III trial of linsitinib for moderate to severe thyroid eye disease, treatment with the highest dose of the investigational, oral insulin-like growth factor 1 receptor inhibitor ...