The groundbreaking research suggests this adaptive response to stress- which the researchers call "split-integrated stress response" or s-ISR-could potentially be exploited to kill cancer cells ...

In response to impaired eIF2B function, cells reduce phosphorylation of eIF2£\ (eIF2£\-p), a crucial regulator of the integrated stress response (ISR). By lowering eIF2£\-p levels, cells ...