An animal care technician at Georgia State University noticed that a 21-month-old, male Sprague-Dawley rat had an unkempt hair coat and a moderately thin body condition. The rat had been purchased ...

Negative-pressure pulmonary edema (NPPE) occurs when a large, negative intrathoracic pressure is generated against an obstructed upper airway, causing fluid to shift into the lung interstitium.

Intrathoracic obstruction is most severe during ... is increased during inspiration because of the effect of atmospheric pressure to compress the trachea below the site of obstruction.

This results in the right heart relying more heavily on the decreased intrathoracic pressures during inspiration to fill, exaggerating the pressure change, which is measurable. To measure the ...