A differential metabolite panel was identified to be significantly differed in MHO and MAO groups, including L-kynurenine ... phenylalanine metabolism, propanoate metabolism, and valine, leucine ...

Tryptophan 2,3-dioxygenase (TDO), as a key rate-limiting enzyme, is widely involved in tryptophan metabolism and the regulation of various physiological and pathological processes. TDO activity can be ...

In addition, we also identified that kynurenine is a strong marker of COVID-19 severity. The relationship between metabolites ...

Cytokines (eg, TNF-α), hypoxic conditions (eg, HIF1-α), and growth factors (eg, TGF-β) promote the upregulation of kynurenine by tryptophan metabolism and the kynurenine pathway. Elevated kynurenine ...

Researchers have studied the biological processes that drive depression in adults and shown a potential role for the kynurenine pathway, but this is the first time it has been investigated in ...