EurekAlert!16d
Lrrk2 promotes M1 macrophage polarization by enhancing signal transducer and activator of transcription 1 (STAT1) signaling (IMAGE)
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EurekAlert!18d
Lrrk2 promotes M1 macrophage polarization via regulating cytokine (IFN-γ) and TLR4 (LPS)-mediated responses
Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling. This function is dependent on the ...