Periplasmic expression with cytometric screening (PECS) is a powerful and rapid “display-less” technology for isolating ligand-binding proteins from diverse libraries. Escherichia coli ...

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins. In biology, the binding of cellular proteins ...

Researchers led by Truong Son Hy, Ph.D., from the University of Alabama at Birmingham, offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ...

These modules allow the ProteinReDiff framework to capture intricate protein–ligand interactions, improve the fidelity of binding affinity predictions and enable more precise redesigns of ligand ...

Knowledge of the ligand-binding regions is also extremely valuable for structure-based drug design and biological hypothesis generation. Traditional methods for determining binding sites and ...

The Federal Circuit affirmed six PTAB decisions that held unpatentable as obvious 79 claims of three Cytiva Bioprocess (“Cytiva”) challenged ...