De Duve named these new organelles "lysosomes" to reflect their lytic ... They observed that the outer membrane of the mitochondria was the main membrane source, with some contribution from ...

Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...

Cells have various quality control mechanisms to detect and repair dysfunctional mitochondria, but when the organelles are too damaged, the cell degrades them using lysosomes. We wanted to determine ...

The protein Spns1 helps transport fat molecules out of lysosomes, preventing harmful buildup and offering insights for rare ...

(3) A portion of mitochondria budding off as mitochondria-derived vesicles and fuse with lysosomes for degradation. (4) Depolarised mitochondria undergo morphological remodelling to squeeze their ...

Breakthrough NUS discovery sheds light on cellular recycling mechanism and potential for treating rare diseases Singapore ...

More information: Xiaowen Ma et al, Perspectives of mitochondria-lysosome-related organelle in hepatocyte dedifferentiation and implications in chronic liver disease, eGastroenterology (2024). DOI ...

The humble lysosome, which carries out so many essential functions, appears to live a double life as a potential traitorous agent. "The study highlights the close interaction between lysosomal ...