MDM2（小鼠双微体 2）作为一种泛素连接酶，在调节 p53 活性的过程中起着关键作用，就像一个精密的 “开关”，控制着细胞的生长、修复和死亡。 正常情况下，p53 就像一位低调的 “幕后英雄”，被 MDM2 维持在较低水平。可一旦细胞受到压力，p53 就会迅速 ...

在辐射诱导衰老的 IMR90 人成纤维细胞实验中，敲低 p53 会使 CCF 形成显著增加，而激活 p53，无论是通过外源性表达 p53，还是抑制 MDM2（MDM2 是 p53 的负调控因子），都能有效抑制 CCF 的形成。此外，MDM2 抑制剂（MDM2i）对 CCF 形成的抑制作用依赖于 p53，且这种抑制 ...

Furthermore, Mdm2 not only functions as an E3 ligase in the degradation of p53, but is also involved in exporting p53 out of the nucleus before its degradation.

Researchers from Walter and Eliza Hall Institute of Medical Research, The University of Melbourne and affiliated organizations presented the development of a new reporter mouse model designed to study ...

enhancing MDM2 transcription independent of p53. Researchers from the University of Houston and Baylor College of Medicine presented preclinical data for MA-242, a dual inhibitor of MDM2 and NFAT1, ...

My colleagues and I are studying two other closely related proteins that regulate p53 by marking it for destruction when it's no longer needed. These proteins, called MDM2 and MDMX, become ...

MDM2, on the other hand, is one of the most frequently studied oncogenes and is an excellent target for cancer therapy, based on its p53-dependent and p53-independent oncogenic activities in ...