We are encouraged by the FDA’s Fast Track designation for BIIB080, which highlights the urgent need for innovative treatments targeting tau pathology in Alzheimer’s disease,” said Priya Singhal, M.D., ...

We have developed a series of targeted mice expressing frontotemporal-dementia-causing mutations in the humanized MAPT gene to investigate the earliest stages of tauopathy." Tau ...

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction, Alzheimer's & Dementia (2025).

These phosphorylated tau species are elevated in the serum not only of AD patients, but also in people with ALS, who likely produce it in their muscles, according to the authors’ findings. Serum ...

Get Instant Summarized Text (Gist) Glutamate, a neurotransmitter, can lead to a toxic buildup of tau protein, contributing to Alzheimer's and related diseases. Research using lab mice and human ...

USC Stem Cell scientists discover a new way to rid cells of toxic tau protein in a study involving mice and lab-grown human “mini-brains,” known as organoids. The neurotransmitter glutamate is ...

Get Instant Summarized Text (Gist) Hormone therapy (HT) in women over 70 is linked to faster tau accumulation, a marker of Alzheimer's disease, especially if initiated more than a decade prior. No ...

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction. Alzheimer's & Dementia , 2025 DOI: 10. ...