Here, we summarize recent progress in tackling the problem of parasite resistance and discuss the underlying molecular mechanisms that confer resistance to current antimalarial agents as far as ...

Knowledge of a drug's mechanism of action enables better dosing through monitoring of the drug's effects on the target pathway in the patient. For example, the proper statin dosage for a given ...

Nitisinone, a drug that is already used to treat two genetic diseases, could be repurposed to control the spread of malaria, ...

The emergence of drug-resistant parasites thwarts efforts to control human malaria. How can we understand the mechanism of drug ... control depends heavily upon antimalarial drugs that kill ...

BCG is also used as a biotherapy for superficial bladder carcinoma. Despite being the most successful cancer biotherapy, the mechanism of action and determinants of response to BCG remain obscure. We ...

Dolutegravir is not an inducer or inhibitor of CYP450 or uridine diphosphate glucuronosyltransferase enzymes and therefore is associated with few drug interactions other than metformin and dofetilide.