they transitioned the astrocytes to a pathogenic state by adding microglia-derived cytokines, which are the molecular cues that induce reactivity in neurodegenerative diseases. 2 Using this system to ...

Strategies to detect and modulate the activity of microglia, astrocytes and oligodendrocytes could help tilt the inflammatory balance in the right direction to treat neurodegenerative diseases ...

Alongside microglia, astrocytes play a pivotal role in supporting brain functions, including metabolism, neurotransmitter ...

Astrocytes are star-shaped glial cells in ... "With our colleagues at AbbVie Inc, we also studied progression of microglia, endothelial, and neuronal cells in AD," added Das.

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

In a recent study published in PNAS, Zhang showed that the transcription factor DLX2 can convert astrocytes into progenitors that produce various cell types, including neurons. 3 These findings ...

Using a single-cell sequencing technique, Brazilian researchers have created the first cell atlas of focal cortical dysplasia ...

We use induced pluripotent stem cells (iPSCs) representing neurological and psychiatric diseases. Differentiation of iPSCs into neurons, astrocytes, microglia allow us to analyze aberrant gene and ...

Differentiation of iPSCs into neurons, astrocytes and microglia allow us to analyze aberrant gene and protein expression, function and metabolism in developing and maturing human brain well before the ...

Xenon is one of the six noble gases. Its name derives from the Greek word for “strange”. In medicine, it has been used as an ...

Over the last decade, Dr. Fossati’s lab has developed robust and efficient protocols to generate human oligodendrocytes, astrocytes, microglia, neurons and complex 3D organoid cultures with the full ...