Dihydroergotamine (DHE) is an ergotamine analog (Figure 3). DHE is administered as a nasal spray form (Migranal®, Valeant Pharmaceuticals, QC, Canada) or by injection. Ergotamine (Ergomar ...

which got the go-ahead from the FDA for its Trudhesa nasal spray product in 2021, and Bausch Health’s well-established Migranal brand, which has been on the market since the late 1990s.