Finally, in a humanized mouse model of immune reconstitution, in which NSG mice were engrafted with human CD34 + stem cells, IVIG transiently inhibited B-cell reconstitution, whereas peripheral T ...

Humanized Immune System Mice The human immune system differs substantially from the immune system of mice, so it is difficult to directly translate research breakthroughs in mice to humans. This makes ...

Humanized mouse models, where human tumor tissue is engrafted into immunodeficient mouse models, are now being used in oncology and infectious disease studies to provide valuable translational insight ...