引言治疗基因的"快递车"竟然自带"拼单"功能？研究人员发现了一个颠覆认知的现象：当两种携带不同"导航系统"的腺相关病毒（AAV）进入大脑，它们竟会像拼图般组合基因片段，将原本4.7kb的运载极限瞬间突破——这种被命名为"转录串扰"（Transcrip ...

1B). In all cases, the flap sequence significantly enhanced GFP transduction mediated by the HIV vector. Figure 1: The HIV-1 central DNA flap enhances gene transduction of primary neural cells.

Previous efforts to circumvent the problem of the size limitation imposed by the AAV vector have focused mainly on altering the candidate genes into ‘mini-expression cassettes’ suitable for ...