Necroptosis is a form of programmed necrosis. Necroptotic stimuli promote the interaction of the RIP1 and RIP3 kinases under conditions in which caspase-8 is not active. This RIP1/RIP3 complex ...

Necroptosis, a pathway responsible for programmed cell death, plays a significant role in the loss of RGCs. Unlike other ...

A study has uncovered that iron orchestrates the activation of two damaging cell death pathways—ferroptosis and necroptosis—early in ischemic stroke recovery, exacerbating brain injury.