Medscape1 个月
Mechanisms of Disease: DNA Repair Defects and Neurological Disease
Five of the conditions (xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy, Down syndrome, and triple-A syndrome) display a defect in the nucleotide excision repair pathway ...
Medscape12 天
Mechanisms of Disease: DNA Repair Defects and Neurological Disease
Abbreviations: BER, base excision repair; DSB, double-stand break; ERCC2, xeroderma pigmentosum complementing protein D; ERCC3, xeroderma pigmentosum complementing ...
Nature1 个月
Passing the baton in base excision repair
it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic representation of single-nucleotide BER and alternatives for aborted intermediates. Recent ...