Five of the conditions (xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy, Down syndrome, and triple-A syndrome) display a defect in the nucleotide excision repair pathway ...

Here we show a unique and previously unrecognized mechanism of drug action in which Et743 subverts normal nucleotide excision repair (NER ... indicated a NER defect of the host cells.

Table 1 lists these disorders along with the known genetic DNA repair defect and the nature of ... complementing protein B; NER, nucleotide excision repair; pol η, polymerase η; SSB, single ...