it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic representation of single-nucleotide BER and alternatives for aborted intermediates. Recent ...

Nucleotide excision repair, genome stability ... Regulation of DNA double-strand break repair pathway choice. Cell Research 18, 134–147 (2008). Singh, R. K. & Krishna, M. DNA strand breaks ...

Five of the conditions (xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy, Down syndrome, and triple-A syndrome) display a defect in the nucleotide excision repair pathway ...

The first four disorders seem to result from defects in the excision repair pathway. In view of their ... pigmentosum complementing protein B; NER, nucleotide excision repair; pol η, polymerase ...

The genetic connections between DNA repair pathways ... completion of DNA excision repair. In contrast, yeast DNA ligase IV is not essential for cell growth. However, deletion of the LIG4 gene elicits ...

The researchers showed that these DNA breaks are only formed in cells with high levels of DNA repair, specifically those that ...