The Watson-Crick hydrogen bond partners of the bound adenine are substituted by protein atoms, confirming a nucleotide flipping mechanism, and supporting a specific DNA binding orientation by MutY ...

NAD + is a coenzyme that plays a crucial role in cellular metabolism. It consists of an adenine nucleotide joined to a nicotinamide nucleotide. NAD + acts as an electron carrier in redox reactions, ...

With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans. Now, researchers at Harvard University have designed a new class ...