the mechanisms by which p53 mediates cell-cycle arrest or apoptosis still remain unclear. There must be some way to specify which target genes of p53 are to be selected. The different serine ...

In addition to these decisions, which are made in the G1 phase of the cell cycle, checkpoints that operate ... but many of these signals feed into the p53 pathway.

Wild-type p53 is often engaged in response to cellular damage, where it acts to regulate genes that promote cell-cycle arrest, apoptosis, senescence, differentiation, and autophagy (Figure 1). In ...

One group showed that p53 controlled the progression of the cell cycle, but it wasn’t clear how. 24 Guillermina Lozano entered the p53 field as a postdoctoral fellow in Levine’s lab in 1985 and ...

p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged cells before they can become malignant. However, in more than 50% of ...

Cell cycle regulation, which determines the process of regular cell division, also no longer functions correctly. In addition, the so-called p53 regulation is significantly altered in these cells ...