The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature ...

Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. Figure 2: Destructive pathways: SUMOylation of Mdm2 ...

This is where p53 comes in. It acts like a vigilant proofreader, detecting errors in DNA and deciding how to handle them. If the damage is minor, p53 instructs the cell to repair it. But if the ...

In case of DNA damage, the p53 protein has the task of blocking the proliferation of the affected cell, thus providing extra time for repairs. Should this repair fail, the cell self-destructs and ...

Navtemadlin is an MDM2 inhibitor that can help to kill cancer cells by boosting the activity of p53, a protein that controls cell growth and induces cell death in response to DNA damage.

Additionally, RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were utilized.