1) of p53 programs p53 responses to stress ... a compact molten globule before acquiring the fixed three-dimensional structure. In certain cases this process depends on the aid of molecular ...

The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised, shedding light on the genetic Achilles' heel of many tumors. In a recent perspective published ...

For example, scientists have developed small molecules that can bind to mutant p53 and stabilize its faulty structure, restoring its ability to bind DNA and regulate genes. Drugs like PRIMA-1 and ...