PARP inhibitors target molecular repair mechanisms especially critical to the proliferation of cancer cells. PARP-1 is an enzyme directly involved in repairing single-stranded DNA breaks.

Other PARP inhibitors have validated the mechanism of action in cancers of the ovary, breast, prostate and pancreas. IDX-1197 has several key advantages over those commercially available PARP ...

Priya Hays, Hays Documentation Specialists, discusses innovations and advancements in the development of personalized cancer ...

Ovarian Cancer Targeted Medication: PARP Inhibitors, Anti-Angiogenic Drugs, Immunotherapy, and More Ovarian cancer is the malignancy with the highest rate of death from tumors of the female ...

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are promising cancer treatments because they block a cell’s ability to repair DNA damage. Four PARPis are currently approved for use in the ...

PARP inhibitors work by working on a DNA repair mechanism that is present in certain fast-growing tumours – blocking the action of the PARP protein that is part of the mechanism causes cancer ...

while being much more effective at “trapping” PARP1 to inhibit the DNA damage repair mechanism. “There was a real reason to think that dialling out PARP2 might make PARP inhibitors better ...

I would like to further investigate the underlying mechanism of this combination drug and optimize the dosage. In our study, we used lower dosages of both AZA and BMN673 at a fixed ratio of one to one ...

Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...

In a video interview, William K. Oh, MD, director of precision medicine at Yale Cancer Center and Smilow Cancer Hospital discusses the latest breakthroughs in advanced prostate cancer treatment.

The withdrawal was due to updated information on the negative impact on overall survival seen in two studies with PARP inhibitors in that same setting. The mechanism of action for EIS-12656 is ...

While all poly ADP-ribose polymerase (PARP) inhibitors improved progression-free survival, olaparib significantly extended overall survival (OS), making it a preferred option.