DNA damage and repair refers to the ... chromatin remodelling enzyme sensitizes cells to PARP inhibitors via reduced abasic site repair, PARP-1 accumulation on chromatin, and replication stress.

This serves two main functions. First, it allows PARP proteins to maintain functionality by returning them to their inactive forms. PARG inhibition results in increases in sensitivity to DNA damage ...

东京国家癌症中心研究所基因组应激信号实验室等多单位的研究人员 Kimiyoshi Yano、Megumi Kato 等，在《Cell Death Discovery》期刊上发表了题为 “PARP inhibition-associated heterochromatin confers increased DNA replication stress ... 包括 A549、H1299、H2172 ...

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are promising cancer treatments because they block a cell’s ability to repair DNA damage. Four PARPis are currently approved for use in the ...

Because a subset of these patients actually have DNA damage repair mutations, we know that adding a PARP inhibitor in the setting of progression has been associated with improvements in survival ...

Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement ...

Professors Ashworth and Jackson each realised that the other had the missing part to their own puzzle: cells could stumble on with just one of BRCA or PARP, but should not be able to survive if both ...

"We suspect there are alternative DNA damage pathways that make endometrial cancer susceptible to PARP inhibition as well." For the next step in their research, Corr and his team plan to perform a ...

Extending their collaboration, Genialis and Debiopharm continue working towards a patient classifier to support WEE1 clinical development Genialis, the RNA biomarker company, today announced an extens ...