Mutations in BRCA2—a gene known to repair damaged DNA and suppress tumor formation—can predict an individual's predisposition to develop breast cancer, ovarian, prostate, pancreatic, and other ...

A study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.

A study led by NYU Langone Health researchers sheds light on how the major cancer gene BRCA2 determines which cancer cells ...

When mutations hinder BRCA2 function, cancer cells are known to rely on the poly ADP-ribose polymerase 1 (PARP1) pathway for back ... in controlling the action of PARP1 at DNA damage sites, and ...

Researchers from the University of Iowa have unveiled the structure of a protein that plays a key role in protecting DNA ...