本文研究揭示了在DNA损伤修复和癌症进展过程中EZH2的功能微调PARP1活性背后的分子机制，这就为联合靶向作用EZH2和PARP1从而治疗癌症提供了一定的 ...

This serves two main functions. First, it allows PARP proteins to maintain functionality by returning them to their inactive forms. PARG inhibition results in increases in sensitivity to DNA damage ...

The PARP & DDR Inhibitors Summit will equip you ... community to optimize & expand current DDR inhibitors including ATR, DNA-PK, PolQ & Rad51 target novel synthetic lethal pairs & develop safe ...

A new study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP ...

RAD52 has already shown promise as a drug target. Inhibitors of the protein can selectively kill cancerous cells while ...

A study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and ...

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are promising cancer treatments because they block a cell’s ability to repair DNA damage. Four PARPis are currently approved for use in the ...