The important pro-fibrotic factors among them include transforming growth factor (TGF)- , connective tissue growth factor (CTGF), platelet-derived growth factor (PDGF), Interleukins ... on the role of ...

Principal investigators Matthias C. Kugler, MD, and John S. Munger, MD, are interested in signaling pathways relevant to lung development and fibrosis. Dr. Munger and collaborators showed that the ...

Several signaling molecules and transcription factors have been identified ... In addition, PPAR-d agonists prevent hepatic fibrosis in experimental rodent models. Many fibrogenic agonists such as ...

The aim of this study is to investigate the role of somatostatinergic and cytokine signalling in hepatic stellate cells (HSC), the effector cells of hepatic fibrosis. Methods The production of ...

Objectives Tissue fibrosis is a major hallmark and a leading cause of death in systemic sclerosis (SSc). Here, we investigated the antifibrotic effects of pomalidomide, an analogue of thalidomide with ...

PDGF and IGF-2 were neutral with respect to their effect on HSC apoptosis. CONCLUSION HSC apoptosis plays a critical role in the spontaneous recovery from biliary fibrosis. Both survival and apoptosis ...

Fibroblasts from eight normal controls, seven patients with interstitial fibrosis associated with a collagen vascular disease (IP-CVD), and 13 patients with sarcoidosis were also examined. Migratory ...

Sirius red and Masson staining, gene expression examination of collagen type I (Coll-I) and fibronectin (FN) were employed to detect myocaridal fibrosis. Gene expression examination of TGF-beta 1, ...

Proliferating HSCs further respond to stimuli derived from scar-associated macrophages and produce collagens and extracellular matrix, thereby promoting liver fibrosis. aHSCs, activated HSCs; PDGF ...