The authors suggest that TGF-β and PDGF direct the response of ... potential for targeting the PI3K pathway. “Targeting growth factor signaling may be an indirect method to reduce cytokine ...

PDGF-AA acted as agents of chaos, binding directly to PDGF receptors on the surface of BM-MSC. This subsequently activated the Hippo signaling pathway, which is responsible for cell regeneration, to ...