The authors suggest that TGF-β and PDGF direct the response of ... potential for targeting the PI3K pathway. “Targeting growth factor signaling may be an indirect method to reduce cytokine ...

PDGF-AA acted as agents of chaos, binding directly to PDGF receptors on the surface of BM-MSC. This subsequently activated the Hippo signaling pathway, which is responsible for cell regeneration, to ...

Taking advantage of the urchin genome project, genes involved in PDGF signaling and the synthesis/modification of proteoglycans ... We recently discovered evidence that a signaling pathway involving ...

These findings suggest that the increase in caveolin-1 levels of the SMCs did not interfere with early events in PDGF signal transduction (Erk1/2 activation), but blocked entrance into the G1 phase of ...

Methods The production of a1-procollagen (a1-PROC) by rat HSCs treated with TNFα (100 ng/ml), TGFβ1 (5 ng/ml) or PDGF (32 ng/ml) and their cellular proliferation with or without octreotide was ...